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. 2018 Aug 9;9:912. doi: 10.3389/fphar.2018.00912

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Copyright © 2018 Li, Luo, Hu, Guo, Yang, Zhang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cyclocarya paliurus leaves (CPAE) treatment alleviates diabetes in diabetic rats. (A) The level of FBG at end of experiment before sacrificed and levels of blood glucose before oral glucose and after glucose administration at 30, 60, and 120 min in glucose tolerance test. (B) Levels of insulin in the serum and pancreas tissue. (C) Histopathological examination of pancreas tissues (H&E staining) (magnification, 200×) and relative islets area in total pancreatic area. The scale bar is 40 μm. (D) Levels of MDA, SOD activities and glutathione concentrations in the serum. (E) Levels of TNF-α and IL-6 in the serum. All data are presented as means ± SEM (n = 6). ^∗p < 0.05, ^∗∗p < 0.001, ^∗∗∗p < 0.0001.