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. 2018 Aug 9;9:912. doi: 10.3389/fphar.2018.00912

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Copyright © 2018 Li, Luo, Hu, Guo, Yang, Zhang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression levels and regulatory network of DEGs in liver tissues of three groups rat models. (A) The counts of DEGs in two comparisons for liver tissues (diabetic-VS-non-diabetic, diabetic-CPAE-VS-diabetic) (n = 3). (B) The expression levels of DEMs for both comparisons in liver tissues (n = 3). Red: up-regulation; green: down-regulation. (C) The miRNA-TF-Target regulatory network for liver tissues (n = 3). Triangle: miRNA; diamond: transcription factor; ellipse: gene; blue: up-regulation in diabetic-VS-non-diabetic and down-regulation in diabetic-CPAE-VS-diabetic; red: down-regulation in diabetic-VS-non-diabetic and up-regulation in diabetic-CPAE-VS-diabetic. (D) Real-time qPCR analysis for miRNA expression (n = 6). ^∗p < 0.05, ^∗∗p < 0.001.