Table 2.
Differentially Expressed Genes in the Comparison Between Blood Samples From Patients With Moderate and Those With Severe Chronic Chagas Cardiomyopathy
| Symbol | Entrez Gene Name | Fold Change | P adjusted |
|---|---|---|---|
| ADGRG1 | Adhesion G protein–coupled receptor G1 | 1.615 | 4.93E−03 |
| ALAS2 | 5’-aminolevulinate synthase 2 | −1.563 | 4.48E−02 |
| BCL2L1 | BCL2-like 1 | −1.562 | 2.50E−02 |
| CES3 | Carboxylesterase 3 | −1.590 | 9.79E−03 |
| FCGR1B | Fc fragment of immunoglobulin G, high-affinity Ib, receptor (CD64) | −1.661 | 5.23E−03 |
| FCGR1C | Fc fragment of immunoglobulin G, high-affinity Ic, receptor (CD64), pseudogene | −1.541 | 6.72E−03 |
| FGFBP2 | Fibroblast growth factor binding protein 2 | 1.504 | 2.19E−02 |
| GK5 | Glycerol kinase 5 (putative) | 1.557 | 6.71E−04 |
| GNLY | Granulysin | 1.504 | 2.90E−02 |
| GZMB | Granzyme B (granzyme 2, cytotoxic T-lymphocyte–associated serine esterase 1) | 1.688 | 1.38E−03 |
| ITLN1 | Intelectin 1 (galactofuranose binding) | −1.581 | 4.02E−02 |
| KIR2DL1/ KIR2DL3 | Killer cell immunoglobulin-like receptor, 2 domains, long cytoplasmic tail, 3 | 2.002 | 1.51E−03 |
| KIR2DL4 | Killer cell immunoglobulin-like receptor, 2 domains, long cytoplasmic tail, 4 | 1.845 | 1.22E−03 |
| KIR3DS1 | Killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 | 2.236 | 4.18E−03 |
| KLC3 | Kinesin light chain 3 | −1.681 | 6.16E−03 |
| KLRC2 | Killer cell lectin-like receptor subfamily C, member 2 | 1.671 | 2.58E−02 |
| KLRF1 | Killer cell lectin-like receptor subfamily F, member 1 | 1.690 | 1.09E−03 |
| KRT1 | Keratin 1, type II | −1.775 | 4.87E−02 |
| MIR181A2HG | MIR181A2 host gene | 1.669 | 5.97E−04 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 1.504 | 1.34E−03 |
| POLR2J4 | Polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene | 2.234 | 2.74E−03 |
| PPDPF | Pancreatic progenitor cell differentiation and proliferation factor | −1.560 | 3.18E−03 |
| PRF1 | Perforin 1 (pore-forming protein) | 1.574 | 1.34E−03 |
| SMIM24 | Small integral membrane protein 24 | −1.536 | 2.57E−02 |
| ST6GALNAC4 | ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 4 | −1.514 | 9.18E−03 |
| TGFBR3 | Transforming growth factor β receptor III | 1.529 | 1.94E−03 |
| TMOD1 | Tropomodulin 1 | −1.544 | 2.47E−02 |
The analysis revealed 27 differentially expressed genes between the 2 groups (fold change, 1.5; cutoff adjusted P < .05).