Fig. 3.

First order DE and genotype signatures of hypoxia. Volcano plots show female (A–H) and male (I–P) differential expression responses to nDNA (A, I), mtDNA (B, J), initial hypoxia (C, K), and longer hypoxic exposure (0–120 min) (D, L). Individual (mtDNA;nDNA) genotype responses to combined hypoxic treatments are shown for OreR;OreR (E, M), siI;OreR (F, N), OreR;AutW132 (G, O) and siI;AutW132 (H, P). Log₂-fold changes are on the abscissa and −log₁₀P-values are shown in the ordinal. Horizontal dashed grey lines highlight P-value =0.05. Vertical dashed grey lines highlight ± 1 on a log₂ fold scale (2 fold up- or down-regulated). Dark purple and dark blue data highlight genes with ± 1 log₂ fold change and P < 0.05, in females and males, respectively.