Fig. 6.

Higher order genetic and hypoxia interactions across sexes. Venn diagrams describe the numbers of genes that were differentially expressed by a higher order interaction (FDR < 0.1). Red circles are female DE genes; blue are male. The numbers of genes that intersected between the sexes are also shown. nDNA × mtDNA significant interactions are shown in (A). mtDNA × hypoxia effects are shown in (B). There were no overlapping genes between the sexes for any of the remaining higher order interactions (B, C, D) with a strict FDR < 0.1 cut-off. nDNA × hypoxia effects (C) and nDNA × mtDNA × hypoxia (D) are shown.