Fig. 1.

Representative autoradiograms of coronal male rat brain sections. Left: distribution of CB1 mRNA levels using in situ hybridization of ³⁵S-labelled oligodeoxynucleotide probe specific for the CB1 mRNA. Right: distribution of [³H]CP55,940 binding levels. The boundaries or the width of quantified brain regions are shown at the level of prefrontal cortex (A, B), at approximate 3.20 mm and 4.20 mm anterior to Bregma, respectively, at the level of striatum (C, D), at approximate 0.96 mm anterior to Bregma, and at the level of dorsal hippocampus (E, F), at approximate -3.00 mm posterior to Bregma according to Paxinos and Watson (2007). Insets indicate the non-specific hybridization signal (left) or non-specific binding (right) in adjacent sections. Cg1: anterior cingulate cortex, PrL: prelimbic cortex; IL: infralimbic cortex; MO: medial orbital cortex; CPu: caudate-putamen, or striatum; CPu-DL: dorsolateral striatum; CPu-VM: ventromedial striatum; NAc: nucleus accumbens; CA1: hippocampal region CA1; CA3: hippocampal region CA3; DG: dentate gyrus; BLA: basolateral amygdala; CeA: central amygdaloid nucleus.