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. 2018 May 28;5:1–9. doi: 10.1016/j.ibror.2018.05.002

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Effects of neonatal handling on cannabinoid receptor binding levels, measured with [³H]CP55,940, of male and female adolescent and adult rat brain. Top: Bar graphs depicting specific [³H]CP55,940 binding levels in male and female rat brain regions of medial prefrontal cortex, caudate-putamen and nucleus accumbens. Bottom: Bar graphs depicting specific [³H]CP55,940 binding levels in male and female rat brain regions of dorsal hippocampus and amygdaloid nuclei. Bars represent mean ± SEM (n = 5–7 animals in each group). Mean values are expressed in fmol/mg. * statistically significant handling effects; # statistically significant age effects; § statistically significant sex effects (p ≤ 0.002 three-way ANOVA with handling, age and sex effect as independent factors). Cg: anterior cingulate cortex, PrL: prelimbic cortex; IL: infralimbic cortex; MO: medial orbital cortex; CPu: caudate-putamen, or striatum; NAc: nucleus accumbens; CA1: hippocampal region CA1; CA3: hippocampal region CA3; DG: dentate gyrus; BLA: basolateral amygdala; CeA: central amygdaloid nucleus.