Table 2:

Classes of independent variables and their eligibility for the self-experimentation framework.

Independent Variable	Example Health-Related Question	Eligibility
Dietary	Does drinking coffee give me heartburn?	Eligible
Actionable Behavior	Does exercising in the morning after waking up give me more energy later in the day?	Eligible
Medications/Supplements
As needed	Does this inhaler reduce my cough?	Eligible
Daily	Is my antidepressant improving my mood?	Ineligible
Environmental
Controllable	Does elevating the head of my bed reduce my heartburn?	Eligible
Uncontrollable	Do I get headaches every time it rains?	Ineligible
Illness/pathogen	Is my mood worse when I’m coming down with the flu?	Ineligible
Combination of variables	Do I sleep better if I both exercise early in the day and stop working one hour before bedtime?	Eligible