Table 2.
Relationship between AP-2α mRNA and clinicopathologic characteristics in papillary thyroid carcinoma patients from The Cancer Genome Atlas databases (N=496)
| Characteristics | Patients, n (N=496) | AP-2α mRNA expression
|
P-value | |
|---|---|---|---|---|
| Low n (%) | High n (%) | |||
| Age (years) | 0.159 | |||
| <45 | 226 | 156 (69) | 70 (31) | |
| ≥45 | 270 | 169 (62.6) | 101 (37.4) | |
| Gender | 0.120 | |||
| Male | 134 | 80 (59.7) | 54 (40.3) | |
| Female | 362 | 245 (67.7) | 117 (32.3) | |
| Tumor size (cm) | 0.747 | |||
| ≤2 cm | 142 | 91 (64.1) | 51 (35.9) | |
| >2 cm | 354 | 234 (66.1) | 120 (33.9) | |
| Tumor stage | 0.011a | |||
| I, II | 331 | 230 (69.5) | 101 (30.5) | |
| III, IV | 165 | 95 (57.6) | 70 (42.4) | |
| Histologic type | 0.019a | |||
| Classical follicular oncocytic | 456 | 306 (67.1) | 150 (32.9) | |
| Tall cell diffuse sclerosing thyroid cancer | 40 | 19 (47.5) | 21 (52.5) | |
| Lymph nodes metastasis | 0.379 | |||
| No | 224 | 136 (60.7) | 88 (39.3) | |
| Yes | 224 | 146 (65.2) | 78 (34.8) | |
| Distant metastasis | 0.341 | |||
| M0 | 277 | 168 (60.6) | 109 (39.4) | |
| M1 | 8 | 3 (37.5) | 5 (62.5) | |
Notes:
a
P<0.05. Pearson’s chi-squared test.
Abbreviation: AP-2α, activator protein 2α.