Table 3.
Univariate and multivariate analyses of prognostic factors for overall survival in papillary thyroid carcinoma from The Cancer Genome Atlas databases (N=496) using Cox regression
| Variables | Univariable P-value | Multivariable
|
|
|---|---|---|---|
| Hazard ratio (95% CI) | P-value | ||
| AP-2α mRNA expression (low vs high) | 0.010 | 0.34 (0.12–0.94) | 0.037 |
| Gender (male vs female) | 0.174 | – | – |
| Age (<45 years vs ≥45 years) | 0.997 | – | – |
| Tumor size (≤2 cm vs >2 cm) | 0.301 | – | – |
| Tumor stage (I, II vs III, IV) | 0.000 | 6.26 (1.99–19.64) | 0.002 |
| Histology type (classical, follicular, oncocytic vs tall cell, diffuse sclerosing, poorly differentiated thyroid cancer) | 0.997 | – | – |
| Distant metastasis (yes vs no) | 0.053 | – | – |
| Lymph nodes metastasis (yes vs no) | 0.516 | – | – |
Note: Statistically significant: P<0.05.
Abbreviation: AP-2α, activator protein 2α.