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. 2018 Aug 13;13:4641–4659. doi: 10.2147/IJN.S166584

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Antitumor efficacy against melanoma pulmonary metastatic tumor-bearing nude mice.

Notes: (A) Lung-mass weight of each treatment group. ^**P<0.01, ^***P<0.001 compared with saline; ^∆P<0.001 compared with Ptx injection; ^#P<0.001 compared with intravenous (IV) PG-SG-Ptx. (B) Body-weight changes as a function of time. Values expressed as means ± SD (n=6). (C) Lung sections isolated on Day 14 after treatment with different Ptx formulations and stained with H&E. Original magnification 4×. Locations of tumors marked with arrowheads. (D) Western blotting analysis: MMP2/9 protein expression in the lungs. (E) Pgp expression in the lungs after inhalation with different Ptx formulations: saline, Ptx injection, P123-Ptx, PG-SG-Ptx.

Abbreviations: P123, Pluronic P123; Ptx, paclitaxel; SG, succinylated gelatin; P123-Ptx, P123 micelles loaded with Ptx; GAPDH, phosphoglyceraldehyde dehydrogenase.