Table 5.
Formulation | GSD | VMD (μm) | Ptx recovery (%), nebulizer/control |
---|---|---|---|
Ptx injection | 1.60±0.07 | 5.75±0.16 | 97.6±4.3 |
P123-Ptx | 1.68±0.07 | 6.01±0.09 | 96.5±3.7 |
PG-SG-Ptx | 1.53±0.01 | 5.92±0.12 | 98.7±4.1 |
Note: Values are expressed as mean ± SD (n=3).
Abbreviations: DSD, droplet-size distribution; GSD, geometric SD; VMD, volume mean diameter; P123, Pluronic P123; Ptx, paclitaxel; SG, succinylated gelatin; PG, P123 modified with GPLGIAGQ-NH2; P123-Ptx, micelles composed of P123 loaded with Ptx.