Table 4.

Percent weight loss (ITT and Completer), Categorical (5% and 10%) and Drops (%)

Drug	ITT* (p value)	Completer (p value)	5% wt loss (p value)	10% wt loss (p value)	Drops (%)
Amphetamine Congeners [8]	N/A (N/A**)	0.23 kg/wk (<0.05, >placebo)	N/A (N/A)	N/A (N/A)	48.5
Lorcaserin [71]	5.81±0.16% (<0.001)	7.1±0.2% (<0.001)	45.5% (<0.001)		44.6%
Placebo	2.16±0.14%	3.0±0.2%	20.3%		54.9%
Topiramate/ Phentermine [58,62]	(<0.0001)	(<0.0001)	(<0.05)	(<0.5)
Placebo	1.6%	2.1%	17.3%	7.4%	47.1%
23/3.75 mg	5.1%	6.7%	44.9%	18.8%	39%
46/7.5 mg	7.8%	9.6%	62%	37%	31%
92/15 mg	10.9%	14.4%	66.7%	47.2%	36%
Bupropion/Naltrexone [39]	(<0.0001)	(<0.0001)	(<0.0001)	(<0.0001)
Placebo	1.3%	1.8%	16%	7%	50%
32/360mg	6.1%	8.1%	48%	25%	50%
Liraglutide [90]	8.0±6.7% (<0.0001)	9% (<0.0001)	63.2% (<0.001)	33.1% (<0.001)	36.6%
Placebo	2.6±5.7%	3.8%	27.1%	10.6% (<0.001)	28.1%

^*ITT = Intent to Treat Analysis

^**N/A = Not Applicable