| Villanueva et al. (2015) |
36-DNA-methylation marker score |
Methylome |
221 + 83 (validation) |
HBV, HCV, alcohol |
[74] |
|
| Wei et al. (2013) |
30-miRNA signature |
miRNA |
60 + 50 (validation) |
HBV |
[75] |
|
| Kim et al. (2012) |
65-gene-based risk score |
mRNA |
139 + 292 (validation) |
HBV |
[76] |
|
| Barry et al. (2012) |
67-miRNA HCC recurrence signature |
miRNA |
69 |
HCV, HBV, NASH |
[77] |
|
| Roessler et al. (2010) |
Metastasis gene signature |
mRNA |
247 +139 (validation) |
HBV |
[78] |
|
| Lee et al. (2004) |
Proliferation cluster of genes |
mRNA |
91 |
HBV, HCV, alcohol, hemochromatosis, Wilson disease |
[67] |
|
| Lee et al. (2006) |
Hepatic progenitor cell signature |
mRNA |
139 |
HBV, HCV, alcohol |
[79] |
|
| Boyault et al. (2007) |
G1-6 transcriptome classification |
mRNA |
120 |
HBV, HCV, alcohol |
[14] |
|
| Nault et al. (2013) |
Five-gene score |
mRNA |
314 + 434 (validation) |
HBV, HCV, alcohol, hemochromatosis |
[21] |
|
| Yamashita et al. (2013) |
EpCAM+/CD90+ gene expression score |
mRNA |
102 |
HBV, HCV, alcohol |
[80] |
|
| Yamashita et al. (2009) |
EpCAM+ gene expression score |
mRNA |
156 |
HBV |
[42] |
|
| Hoshida et al. (2009) |
S1-3 expression-based subclasses |
mRNA |
603 |
HBV, HCV |
[66] |
|
| Minguez et al. (2011) |
35-gene signature of vascular invasion |
mRNA |
79 + 135 (validation) |
HCV |
[81] |
|
| Toffanin et al. (2011) |
miRNA-based classification of HCC |
miRNA |
89 |
HCV |
[82] |
|
| Kurokawa et al. (2004) |
20-gene-based prediction score |
mRNA |
100 |
HBV, HCV |
[83] |
|
| Iizuka et al. (2003) |
Statistical Pattern Recognition method |
mRNA |
33 + 27 (validation) |
HCV, HBV |
[84] |
|
| Wang et al. (2007) |
57-member molecular gene signature |
mRNA |
25 |
HBV, HCV |
[85] |
|
| Woo et al. (2008) |
HCC recurrence signature |
mRNA |
65 |
HBV |
[86] |
|
| van Malenstein et al. (2010) |
Seven-gene signature associated with hypoxia |
mRNA |
272 + 91 (validation) |
HCV, HBV, alcohol, NASH, AIH, PBC |
[87] |
|
| Ye et al. (2003) |
Metastatic HCC gene signature |
mRNA |
67 |
HBV |
[88] |
|
| Yoshioka et al. (2009) |
Prediction score of early recurrence |
mRNA |
139 |
HCV, HBV |
[89] |
|
| Okamato et al. (2006) |
Gene signature for multicentric HCC |
mRNA |
40 |
HCV |
[90] |
|
| Chiang et al. (2008) |
Molecular classification of HCV-associated HCC |
mRNA |
109 |
HCV |
[91] |
|
| Jiang et al. (2008) |
miRNA prognostic signature |
miRNA |
54 |
HCV, alcohol, HBV, hemochromatosis |
[92] |
|
| Budhu et al. (2008) |
20-miRNA tumor signature |
miRNA |
131 + 110 (validation) |
HBV |
[93] |
