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. 2014 Dec 11;1(4):409–421. doi: 10.2217/hep.14.21

Table 3. . Results of liver transplantation for neuroendocrine tumors liver metastases (series of at least 10 patients, published in English after 1990).

Study Postoperative mortality Overall survival Disease-free survival Survival prognostic factors Ref.
Multicentric series

Le Treut 14%, risk factors:
  • DP primary

  • UAE

  • Early re-LT

5 years: 47% 5 years: 20% UAE, DP primary, HMG. DP primary + HMG = 12% 5 year OS [11]

Le Treut 10%, risk factors:
  • Early re-LT

  • UAE

  • Splenectomy

  • Operative time >10 h

  • R1-R2 resection

  • HMG

  • Concomitant surgery

5 years: 52% 5 years: 30% Major concomitant surgery, poorly differentiated tumor, HMG. After 2000: HMG, age >45, concomitant resection [9]

Bechstein 10% 3 years: 52% [4]

N'Guyen 5 years: 49% Low serum albumin level in recipient [7]

Gedaly   5 years: 48% 5 years: 32% Better survival if wait time >67 days [12]

Monocentric series

Coppa 5 years: 67% after LR, 70% after LT (p = NS) 5 years: 29% after LR, 53% after LT (p = NS) [5]

Van Vilsteren 5% (n = 1) 1 year: 87% 1 year: 77% Ki67 correlated with survival, but not with recurrence [13]

Rosenau 5% (n = 1) 5 years: 80% 5 years: 21% % of Ki67-positive cells and aberrant staining pattern for E-cadherin– hepatichilar or regional lymph node at LT [8]

Marin 10% (n = 1) 3 years: 57% [14]

Cahlin 0% 2 years: 10% in carcinoid tumors 2 years: 67% in pancreatic NETs 2 years: 75% in carcinsoid tumors 2 years: 33% in pancreatic NETs [15]

Florman 27% 5 years: 36% [16]

Lang 8% (n = 1) 5 years: 77% [17]

Lang 0 5 years: 40% 5 years: 10% [18]

Routley 0 5 years: 57% [19]

Ahlman 0% [20]

Personal series 12% 5 years: 55% 5 years: 45%  

DP: Duodenopancreas; HMG: Hepatomegaly; LR: Liver resection; LT: Liver transplantation; NET: Neuroendocrine tumor; NS: Not significant; OS: Overall survival; UAE: Upper abdominal exenteration.