Table 2.
Sensitivity analyses to determine the independent cost variables’ impact on the dependent variable of mortality and morbidity benefit
| Cost Categories | Base Value | Lower Limit | Upper Limit | *Cost Lower Range | *Cost Upper Range |
| Dantrolene | $1,008.00 | $700.00 | $1,100.00 | $5,019,859 | $6,195,859 |
| Other Cart Supplies | $237.62 | $100.00 | $400.00 | $5,520,776 | $6,402,776 |
| Pharmacist Time | 3 | 1 | 5 | $5,503,901 | $6,346,857 |
| RN Time | 13 | 10 | 20 | $5,548,985 | $6,803,630 |
| Pharmacist Salary + Benefits (25%) | $71.68 | $30.00 | $100.00 | $5,557,761 | $6,175,161 |
| RN Salary + Benefits (25%) | $42.68 | $25.00 | $75.00 | $5,249,840 | $7,160,840 |
| Number of Hospitals | 2940 | 2471 | 3377 | $4,980,140 | $6,806,124 |
| Effectiveness Categories | Base Value | Lower Limit | Upper Limit | **VSL Lower Range | **VSL Upper Range |
| Dantrolene Intervention MH Mortality | 10% | 1.40% | 11.70% | $3,700,857 | $3,217,928 |
| 30 Minute Dantrolene Treatment Delay | 80% | 50% | 100% | $1,891,045 | $4,235,360 |
| GA rate for CD | 5.80% | 3.00% | 10.00% | $1,823,364 | $5,509,039 |
| GA rate for Non-CD Procedures | 4.51% | 2% | 8% | $3,161,956 | $3,486,287 |
| Rate of Non-CD Procedures | 3.20% | 2% | 4% | $3,204,348 | $3,361,121 |
| Number of Births | 3988076 | 3988076 | 3988076 | $3,297,634 | $3,297,634 |
| Rate of CD of all L&D visits | 32.20% | 15.00% | 42.00% | $1,666,388 | $4,227,065 |
| Number of GA Cases per MH Case | 170968 | 341936 | 85484 | $1,648,817 | $6,595,269 |
| Fetal mortality | 0% | 40% | $3,297,634 | $4,864,306 | |
| Fetal morbidity | 10% | 50% | $3,298,880 | $3,303,862 |
*
Cost = Estimated yearly cost per maternal and fetal lives saved by maintaining a malignant hyperthermia cart on a maternity ward
**
VSL = Estimated yearly maternal and fetal value of statistical lives
Cost-benefit is achieved when VSL is greater than lowest cost value.
RN=registered nurse; CD=cesarean delivery; GA=general anesthesia; MH=malignant hyperthermia; L&D=labor and delivery