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. 2016 May 5;25(13):2789–2800. doi: 10.1093/hmg/ddw136

Figure 1.

Figure 1.

EZH2 is upregulated and associated with aggressive ACC in patients. (A) Expression levels of EZH2 in patients. Boxplots represent the expression levels of EZH2 in NAd (green), ACA (blue) and ACC (red), from two independent cohorts (Cochin and Michigan). (B) Expression of EZH2 in an independent group of patients. mRNA accumulation of EZH2 was evaluated by RTqPCR in 7 ACA and 7 ACC from the COMETE network. (C) EZH2 protein is overexpressed in ACC. Accumulation of EZH2 protein was evaluated by western blot in 7 ACA and 7 ACC from the COMETE network. (D)EZH2 expression is correlated with Ki67 and PCNA. Pearson correlation between log2 values of EZH2 expression and expression of Ki67 and PCNA genes in ACC from Cochin, Michigan and TCGA cohorts. P, P-value; r, Pearson correlation coefficient. (E) EZH2 overexpression is associated with poor prognosis. Graphs show Kaplan-Meier estimates of overall survival for patients with ACC, as a function of EZH2 expression (divided as high, medium and low). The P-value of the log-rank test for differences between survival curves is shown.