Table 2.

Enriched Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for 644 genes in the association weight matrix (AWM)

GO term/KEGG pathway	Category	P-value	AWM gene count	Gene count in each category
Glycoprotein biosynthetic process	GO_BP	6.09E-04	10	80
Glycoprotein metabolic process	GO_BP	6.19E-04	11	97
Transmembrane transport	GO_BP	0.0030	23	389
Protein amino acid glycosylation	GO_BP	0.0044	8	69
Biopolymer glycosylation	GO_BP	0.0044	8	69
Glycosylation	GO_BP	0.0044	8	69
Generation of a signal involved in cell-cell signaling	GO_BP	0.0058	6	39
Enzyme linked receptor protein signaling pathway	GO_BP	0.0084	11	138
Neurotransmitter secretion	GO_BP	0.0155	4	18
Multicellular organismal movement	GO_BP	0.0170	3	7
Musculoskeletal movement	GO_BP	0.0170	3	7
Neuropeptide signaling pathway	GO_BP	0.0177	6	51
Ion transport	GO_BP	0.0187	25	511
Biological adhesion	GO_BP	0.0214	17	306
Cell adhesion	GO_BP	0.0214	17	306
Extracellular structure organization	GO_BP	0.0217	7	73
Cation homeostasis	GO_BP	0.0219	9	115
Exocytosis	GO_BP	0.0238	6	55
Cellular calcium ion homeostasis	GO_BP	0.0332	6	60
Regulation of cell morphogenesis	GO_BP	0.0334	5	41
Calcium ion homeostasis	GO_BP	0.0375	6	62
Synaptic vesicle transport	GO_BP	0.0411	3	11
Cellular metal ion homeostasis	GO_BP	0.0446	6	65
Metal ion transport	GO_BP	0.0476	15	285
Cell-cell adhesion	GO_BP	0.0495	9	135
Calcium ion binding	GO_MF	4.39E-05	33	528
Ion binding	GO_MF	7.70E-05	99	2,439
Cation binding	GO_MF	2.45E-04	96	2,415
Metal ion binding	GO_MF	2.60E-04	95	2,387
Sialyltransferase activity	GO_MF	0.0022	5	20
Ion channel activity	GO_MF	0.0044	17	268
Substrate-specific channel activity	GO_MF	0.0049	17	271
Passive transmembrane transporter activity	GO_MF	0.0056	17	275
Channel activity	GO_MF	0.0056	17	275
α-N-acetylneuraminate α-2,8-sialyltransferase activity	GO_MF	0.0077	3	5
Manganese ion binding	GO_MF	0.0105	7	65
Transition metal ion binding	GO_MF	0.0307	62	1,698
ATP binding	GO_MF	0.0354	40	1,018
Cation:cation antiporter activity	GO_MF	0.0379	3	11
Adenyl ribonucleotide binding	GO_MF	0.0397	40	1,027
Cation channel activity	GO_MF	0.0476	10	165
O-Glycan biosynthesis	KEGG_Pathway	0.0020	6	30
Axon guidance	KEGG_Pathway	0.0026	11	114
Glycosphingolipid biosynthesis	KEGG_Pathway	0.0083	4	14
Phosphatidylinositol signaling system	KEGG_Pathway	0.0219	7	71
Lysosome	KEGG_Pathway	0.0232	9	113
MAPK1 signaling pathway	KEGG_Pathway	0.0271	15	257
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG_Pathway	0.0498	6	65

¹MAPK = mitogen-activated protein kinase.