Table 3.
Serum (mean ± SD) concentrations of free carnitine and acylcarnitines (µmol/L) in diseased and healthy milus and in control horses1 and horses with EAM2 (nonsurvivors)1
| Healthy milus (n = 11) | Diseased milus nonsurvivors (n = 10) | Control horses (n = 44) | Horses with EAM nonsurvivors (n = 40) | |
|---|---|---|---|---|
| Free carnitine | ||||
| Free carnitine | 79.42 ± 61.86 | 121.11 ± 50.31 | 26.02 ± 1.07 | 87.04 ± 7.95 |
| Short-chain acylcarnitines (C2 to C5) | ||||
| C2-carnitine | 13.02 ± 9.42 | 20.00 ± 11.36 | 8.77 ± 0.67 | 55.23 ± 4.24 |
| C3-carnitine | 0.50 ± 0.44 | 0.65 ± 0.40 | 0.56 ± 0.03 | 2.92 ± 0.27 |
| C3DC-carnitine | 0.04 ± 0.04 | 0.06 ± 0.03 | 0.03 ± 0.00 | 0.34 ± 0.04 |
| C4-carnitine | 1.42 ± 2.70 | 6.23 ± 6.44 | 0.36 ± 0.02 | 26.62 ± 3.67 |
| C5-carnitine | 0.68 ± 1.22 | 2.06 ± 1.61 | 0.21 ± 0.01 | 24.71 ± 3.20 |
| C5-OH-carnitine | 0.08 ± 0.04** | 0.11 ± 0.05** | 0.06 ± 0.0 | 0.56 ± 0.07 |
| C5DC-carnitine | 0.29 ± 0.48 | 0.51 ± 0.56 | 0.18 ± 0.01 | 2.20 ± 0.28 |
| Medium-chain acylcarnitines (C6 to C10) | ||||
| C6-carnitine | 0.06 ± 0.10*** | 0.39 ± 0.45*** | 0.04 ± 0.00 | 5.40 ± 0.81 |
| C8-carnitine | 0.06 ± 0.09 | 0.17 ± 0.15 | 0.02 ± 0.00 | 1.45 ± 0.18 |
| C8:1-carnitine | 0.04 ± 0.05 | 0.04 ± 0.02 | 0.09 ± 0.01 | 1.26 ± 0.15 |
| C10-carnitine | 0.04 ± 0.07 | 0.13 ± 0.12 | 0.02 ± 0.00 | 0.76 ± 0.09 |
| C10:1-carnitine | 0.02 ± 0.02 | 0.03 ± 0.02 | 0.05 ± 0.01 | 0.67 ± 0.07 |
| C10:2-carnitine | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.03 ± 0.00 | 1.31 ± 0.14 |
| Long-chain acylcarnitines (C12 to C18) | ||||
| C12-carnitine | 0.16 ± 0.38 | 0.34 ± 0.22 | 0.04 ± 0.01 | 0.28 ± 0.03 |
| C12:1-carnitine | 0.04 ± 0.09 | 0.06 ± 0.04 | 0.02 ± 0.00 | 0.23 ± 0.03 |
| C14-carnitine | 0.22 ± 0.56 | 0.63 ± 0.42 | 0.03 ± 0.00 | 0.21 ± 0.02 |
| C14:1-carnitine | 0.07 ± 0.15 | 0.23 ± 0.15 | 0.03 ± 0.00 | 0.32 ± 0.04 |
| C16-carnitine | 0.80 ± 2.27 | 2.59 ± 1.8 | 0.14 ± 0.04 | 0.68 ± 0.07 |
| C16:1-carnitine | 0.13 ± 0.36 | 0.40 ± 0.28 | 0.02 ± 0.00 | 0.24 ± 0.03 |
| C18-carnitine | 0.33 ± 0.68 | 2.81 ± 1.86 | 0.07 ± 0.01 | 0.28 ± 0.02 |
| C18:1-carnitine | 0.31 ± 0.85 | 0.77 ± 0.44 | 0.04 ± 0.01 | 0.57 ± 0.06 |
2EAM = equine atypical myopathy.
**P < 0.01; ***P < 0.001; superscripts indicate statistically greater values in diseased vs. healthy milus.