Table 6.

Effect of graded levels of guanidinoacetic acid (GAA) on the concentration of GAA and its metabolites in serum (Exp. 1)

Item	GAA, mg/kg					SEM	P-value
	0	300	600	900	1,200		ANOVA	Linear	Quadratic
day 35
GAA, μg/mL	1.09	1.14	1.00	1.09	0.90	0.08	0.29	0.64	0.53
Creatine, μg/mL	22.94ab	28.03a	17.06b	20.21ab	24.56ab	2.44	0.04	0.12	0.25
Creatinine, μmol/mL	93.57	91.82	95.43	92.72	97.94	5.61	0.94	0.81	0.84
day 70
GAA, μg/mL	0.70	0.88	0.68	0.75	0.79	0.06	0.19	0.97	0.16
Creatine, μg/mL	24.00	26.22	18.85	19.11	21.22	3.45	0.51	0.28	0.63
Creatinine, μmol/mL	98.51	93.06	96.91	95.70	95.58	4.48	0.94	0.77	0.56
day 98
GAA, μg/mL	1.00	1.36	1.09	1.25	1.03	0.10	0.12	0.10	0.41
Creatine, μg/mL	33.35	36.66	31.86	31.77	25.87	2.91	0.15	0.77	0.94
Creatinine, μmol/mL	102.05	98.36	97.00	91.95	94.97	3.92	0.47	0.16	0.96

Data are the means of six replicates of one pig per pen.

^a,bMeans with different superscripts within a row differ (P ≤ 0.05).