Table 1. . Summary of miRNAs expression studies in cholangiocarcinoma.

Study (year)	MiRs upregulated in CCA compared to controls	MiRs downregulated in CCA	Study CCA model	Ref.
Kawahigashi et al. (2009)		22, 125a, 127, 199a, 214, 376a, 424	CCA cell line (TFK, HuCCT1, MEC)	[40]
Meng et al. (2006)	21†, 200b, 141		CCA cell line (KMCH-1, Mz-ChA-1, TFK)	[41]
Yang et al. (2014)	29b-1, 7, 34b, 146a, 192, 194, 203, 215, 221, 361-3p, 375, 582-5p, 625†, 892b	135b, 144, 200a/b/c†, 204, 429, 451†, 486-5p, 495, 513a-5p, 1826	Human CCA tissue (three CCA, three matched normal)	[42]
Zhang et al. (2015)	92b-5p, 188-5p, 331-3p 423-5p, 491-5p, 566, 612, 625-3p†, 675-5p, 765	19b-3p, 24-3p, 26a-5p, 29a, 29c-3p, 99a-5p, 100-5p, 101-3p, 103a-3p, 130a-3p, 141-3p, 143-3p, 338-3p†, 451a†, 497-5p, let-7a†, let-7d, let-7e, let-7f	Human CCA tissue (66 CCA, nine matched normal)	[39]
Karakatsanis et al. (2013)	21†, 31, 223†	122, 145†, 200c†, 221, 222†	Human CCA tissue (21 CCA, 60 HCC, 98 controls)	[38]
Chen et al. (2009)	15a, 15b, 17-5p, 17-3p, 19a, 20, 21†, 25, 103, 106a, 130b, 142-3p, 193, 223†, 224, 331, 324-5p, 374	98, 145†, 184, 185, 197, 198, 200c†, 204, 214, 222†, 302b, 302d, 320, 328, 337, 338†, 371, 373, let-7a†, let-7b	Human CCA tissue (27 CCA, 18 controls)	[43]

^†miRNA with evidence for a role in CCA from more than one study.

CCA: Cholangiocarcinoma; HCC: Hepatocellular carcinoma.