Table 1. Results of local response and survival in recent studies.
Study (year) | Local response (%) | Survival (%) | Comment | Ref. |
---|---|---|---|---|
Varela et al. (2007) | Response: 66 PR: 44.4† SD: 25.9† CR: 25.9‡ |
At 12 months: 92.5 At 24 months: 88.9 |
On intention-to-treat | [4] |
Poon et al. (2007) | CR: 6.7 PR: 63.3 |
At 12 months: 92.5 At 24 months: 88.9 |
Prospective study Results at 1 month |
[5] |
Malagari et al. (2008) | CR: 12.2 PR: 75.6 PD: 6.8 SD: 12.2 |
NA | At 9 months after three scheduled sessions Prospective study |
[15] |
Malagari et al. (2008) | CR: 16.1 OR: 72 |
At 18 months: 94.1 At 30 months: 88.2 |
After three scheduled sessions Prospective study |
[16] |
Kettenbach et al. (2008) | CR: 27 PR: 13 PD: 40 SD: 3 |
At 6 months: 93 | Prospective study | [17] |
Sacco et al. (2011) | CR: 51.5§ PR: 48.5§ PD: 17.9 |
At 24 months estimated: 86.8 | Prospective–randomized study | [18] |
Sycha et al. (2012) | OR: 89% | NA | NA | [20] |
Dhanasekaran et al. (2010) | NA | At 6 months: 71 At 12 months: 58 At 24 months: 48 Median survival 610 days§ |
Retrograde study | [22] |
Lammer et al. (2010) | CR: 27§ OR: 52§ DC: 63§ |
NA | Prospective–randomized study | [24] |
Malagari et al. (2012) | CR: 22.5–23.5¶ PR: 46.5–49¶ PD: 8.4–4.9¶ SD: 22.5¶ |
At 12 months: 93.6 At 24 months: 83.8 At 3 years: 62.0 At 4 years: 41.0 At 5 years: 22.5 Mean overall survival: 43.8 months |
Prospective study After three scheduled sessions and then on demand |
[27] |
Burrel et al. (2012) | NA | Median survival after censoring at the time of transplant/sorafenib was 47.7 months |
Prospective study | [28] |
†Response Evaluation Criteria In Solid Tumors criteria.
‡WHO-modified criteria.
§In the DC Bead™ arm.
¶Range for Child–Pugh A and Child–Pugh B cirrhosis.
CR: Complete response; DC: Disease control (complete response plus partial response plus stable disease); NA: Not applicable; OR: Objective response (complete response plus partial response); PD: Progressive disease; PR: Partial response; SD: Stable disease.