. 2017 Jan 20;3(4):223–239. doi: 10.2217/hep-2016-0009

Table 2. . Factors prognostic of overall survival of patients with intrahepatic cholangiocarcinoma treated with curative intent, as reported in the latest published series.

Study	Study period	Number of patients	Poor prognostic factors			Ref.

			*Not associated with overall survival*	*Univariate prognostic factors*	*Independent prognostic factors*
De Jong et al.	1973–2010	449	Biliary invasion Direct invasion	Large tumor size Multiple tumors Vascular invasion Lymph node metastasis	Multiple tumors Vascular invasion Lymph node metastasis	[22]

Ribero et al.	1990–2008	434	Age Sex Serum CEA Tumor macroscopic type Perineural invasion Adjuvant treatment	High serum CA 19-9 Poor tumor differentiation Lymph node metastasis Vascular invasion Large tumor size Multiple tumors Radical resection	High serum CA 19-9 Lymph node metastasis Multiple tumors	[12]

Wang et al.	2002–2007	367	Age Sex Hepatitis B Vascular invasion Surgical margin (<1 versus ≥ 1) Presence of intact capsule Cirrhosis Microvascular invasion	Elevated laboratory values (Serum CEA, CA 19–9, total bilirubin, albumin, GGT) Blood transfusion Large tumor size Multiple tumors Lymph node metastasis Vascular invasion Direct invasion Local extrahepatic metastasis	High serum CEA and CA 19-9 Large tumor size Multiple tumors Lymph node metastasis Vascular invasion Direct invasion Local extrahepatic metastasis	[75]

Jiang et al.	1998–2008	344	Age Sex Hepatitis B Vascular invasion	Low serum albumin High serum ALP and serum CA 19-9 Multiple tumors Large tumor size (≥10 cm) Obscure tumor boundary	Multiple tumors Large tumor size Obscure tumor boundary High serum ALP and CA 19-9	[123]

Farges et al.	1998–2008	212	NR	Pathologic TNM staging Large tumor size Satellite nodules Vascular invasion Lymph node metastasis R1 resection	Pathologic TNM staging	[127]

ALP: Alkaline phosphatase; CA: Carbohydrate antigen; CEA: Carcinoembryonic antigen; CN: China; FR: France; GGT: Gamma glutamyl transferase; ICC: Intrahepatic cholangiocarcinoma; IT: Italy; MC: Multicenter; MN: Multinational; NR: Not reported; OS: Overall survival.