Table 1. . Pharmacokinetics of chemotherapeutics delivered via the hepatic artery.

Drug	% Hepatic extraction	Plasma half-life (min)	Fold increase exposure with hepatic arterial infusion	Retained systemic exposure relative to iv. administration (%)
5-fluorouracil	22–45	10	5–10	60–70
Oxaliplatin	47	900–1140	4:3	–
Floxuridine	69–92	<10	100–400	<5
Mitomycin C	22	≤10	6–8	80–90
Cisplatin	–	20–30	4–7	100
Doxorubicin	45–50	60	2	40–50

iv.: Intravenous.

Adapted from [20].