Table 4.
Pharmacokinetic parameters adjusted for dose following administration of tulathromycin (Draxxin 100 mg/mL, Zoetis, Kalamazoo, MI) injected using a Type U 10.0 cc ¾ inch 14 GA Needle pneumatic dart (Pneu-Dart, Williamsport, PA) administered with a Model 178B breech loading projector (Pneu-Dart, Williamsport, PA) (remote drug delivery [RDD]; n = 11) or subcutaneous injection (INJ; n = 8)
| Parameter | Group | Mean | SEM | Lower 95% | Upper 95% | P-value |
|---|---|---|---|---|---|---|
| AUCall (h*ng/mL) |
INJ | 11485.79 | 451.20 | 10,418.87 | 12,552.71 | 0.005 |
| RDD | 8433.53 | 811.10 | 6,626.29 | 10,240.78 | ||
| Cl/F obs (mL/min/kg) |
INJ | 3.56 | 0.12 | 3.26 | 3.85 | 0.025 |
| RDD | 5.03 | 0.55 | 3.80 | 6.26 | ||
| Cmax (ng/mL) |
INJ | 153.49 | 28.67 | 85.69 | 221.30 | 0.3 |
| RDD | 206.45 | 40.63 | 115.92 | 296.97 | ||
| Half-life (T1/2) (h) | INJ | 111.65 | 2.97 | 104.63 | 118.67 | 0.66 |
| RDD | 103.95 | 16.68 | 66.79 | 141.10 | ||
| Tmax (h) |
INJ | 1.00 | 0.72 | -0.69 | 2.69 | 0.33 |
| RDD | 0.27 | 0.02 | 0.22 | 0.32 | ||
| Vz/F obs (L/kg) |
INJ | 34.37 | 1.46 | 30.92 | 37.82 | 0.43 |
| RDD | 39.36 | 5.91 | 26.19 | 52.53 |
AUCALL = area under the curve for all timepoints; Cl/F obs = the observed Cl per fraction of the dose absorbed; CMAX = maximum plasma concentration; TMAX = time to CMAX; T ½ = terminal half-life; Vz = volume of distribution, area method; Vz/F = Vz per fraction of the dose absorbed.