Table 1.
Genes integrating the atherosclerosis pathway
| Symbol | Entrez gene name | Fold change1 | FDR2 | Location | Type(s) |
|---|---|---|---|---|---|
| RBP4 | Retinol binding protein 4, plasma | 6.461 | 1.13E-09 | Extracellular space | Transporter |
| PLA2G4D | Phospholipase A2, group IVD (cytosolic) | 6.146 | 2.98E-03 | Cytoplasm | Enzyme |
| CMA1 | Chymase 1, mast cell | 5.912 | 7.36E-04 | Extracellular space | Peptidase |
| CCR2 | Chemokine (C-C motif) receptor 2 | 3.998 | 1.45E-03 | Plasma membrane | G-protein coupled receptor |
| IL33 | Interleukin 33 | 2.655 | 2.40E-05 | Extracellular space | Cytokine |
| PLA2G4F | Phospholipase A2, group IVF | 2.533 | 3.50E-02 | Cytoplasm | Enzyme |
| APOA2 | Apolipoprotein A-II | 2.389 | 7.94E-06 | Extracellular space | Transporter |
| ITGB2 | Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 2.253 | 3.60E-04 | Plasma membrane | Transmembrane receptor |
| PON1 | Paraoxonase 1 | 2.232 | 1.48E-02 | Extracellular space | Phosphatase |
| PLA2G16 | Phospholipase A2, group XVI | 2.21 | 9.76E-04 | Nucleus | Enzyme |
| MSR1 | Macrophage scavenger receptor 1 | 2.181 | 2.17E-02 | Plasma membrane | Transmembrane receptor |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | 2.09 | 9.76E-03 | Plasma membrane | G-protein coupled receptor |
| PDGFA | Platelet-derived growth factor alpha polypeptide | −2.225 | 3.31E-04 | Extracellular space | Growth factor |
| PLA2G3 | Phospholipase A2, group III | −2.448 | 3.23E-03 | Extracellular space | Enzyme |
| APOA1 | Apolipoprotein A-I | −2.681 | 1.01E-02 | Extracellular space | Transporter |
| F3 | Coagulation factor III (thromboplastin, tissue factor) | −2.96 | 1.87E-04 | Plasma membrane | Transmembrane receptor |
| ALOX12B | Arachidonate 12-lipoxygenase, 12R type | −5.499 | 1.67E-02 | Cytoplasm | Enzyme |
1Fold change: Values indicate the relative gene expression. Positive values indicate higher expression in weaned than in suckling calves, and negative values indicate the opposite.
2FDR = false discovery rate.