Table 3.
Upstream regulators activated (z-score > 2.00) and inhibited (z-score < -2.00) in the rumen of Japanese Black cattle during weaning
| Upstream regulator | Molecule type | P-value of overlap1 | Predicted activation state | Activation z-score2 |
|---|---|---|---|---|
| IgG | Complex | 1.38E-09 | Activated | 3.039 |
| Lipopolysaccharide | Chemical drug | 2.35E-13 | Activated | 2.516 |
| Alitretinoin | Chemical drug | 7.57E-06 | Activated | 2.241 |
| PPARδ3 | Ligand-dependent nuclear receptor | 3.40E-07 | Activated | 2.232 |
| PPARα4 | Ligand-dependent nuclear receptor | 3.17E-14 | Activated | 2.155 |
| Pirinixic acid | Chemical toxicant | 2.34E-08 | Activated | 2.075 |
| TNF5 | Cytokine | 6.08E-12 | Activated | 2.007 |
| Estrogen receptor | Group | 1.97E-07 | Inhibited | −2.232 |
1P-value of overlap: Values indicate a statistically significant encrichment of the network-regulated genes in the database.
2 z-Score: Values indicate a statistically significant match between up- and down-regulation patterns.
3PPARδ = peroxisome proliferator-activated receptor delta.
4PPARα = peroxisome proliferator-activated receptor alpha.
5TNF = tumor necrosis factor.