Table 2. . Characteristics and perioperative outcomes of index single hepatectomy and repeat second hepatectomy for metastastic colorectal cancer.
| Study (year) | Bilobar metastases | Number of metastases | Metastases size (cm) | Major hepatectomy | Operative time | Blood loss | Morbidity | Mortality | Ref. | |
|---|---|---|---|---|---|---|---|---|---|---|
| Joönsson et al. (2012) | H1 (n = 240) | – | – | – | – | – | 1000 ± 1786 | 65† | – | [19] |
| H2 (n = 32) | – | – | – | – | – | 1850 ± 1833 | 71 | – | ||
| Kulik et al. (2013) | H1 (n = 932) | 29 | 46‡ | 43§ | 49 | – | – | 16.5 | 1.4 | [20] |
| H2 (n = 94) | 40 | 58 | 37 | 32 | – | – | 9 | 0 | ||
| Wicherts et al. (2013) | H1 (n = 288) | – | 72‡ | 36 (33) | 34 | – | – | 27 | 0 | [21] |
| H2 (n = 288) | – | 53 | 31 (28) | 17 | – | – | 32 | 2.4 | ||
| Yamazaki et al. (2013) | H1 (n = 173) | – | 2 (1–24) | 3.5 (0.8–13.6) | – | 359 (115–579) | 280 (25–3.093) | 27¶ | 0 | [22] |
| H2 (n = 37) | – | 2 (1–13) | 3.0 (1.6–16.1) | – | 395 (178–740) | 307 (15–1.492) | 25 | 0 | ||
| H3 (n = 22) | – | 1 (1–6) | 4.0 (1.9–6.5) | – | 472 (195–616) | 286 (66–1.053) | 33 | 0 | ||
| Battula et al. (2014) | H (n = 916) | – | 1 (1–9) | 3.5 (1.0–18.5) | 82 | – | – | 21 | 4.9 | [23] |
| H1 (n = 53) | – | 1 (1–8) | 3.0 (1–11) | 47 | – | – | 13 | 0 | ||
| H2 (n = 53) | – | 1 (1–3) | 3.0 (1.0–7.5) | 19 | – | – | 8 | 0 | ||
| Ali et al. (2015) | H1 (n = 86) | 27 | 46‡ | 3.5 (2.5–6) | 52 | 200 (160–240) | – | – | 0 | [25] |
| H2 (n = 30) | 20 | 60 | 3.5 (2.5–5.6) | 27 | 228 (189–261) | – | – | 0 | ||
| Lee et al. (2015) | H1 (n = 406) | – | 1 (1–8) | 2.4 (0.2–7.5) | – | 276 (± 101) | – | 17 | – | [27] |
| H2 (n = 55) | – | 1 (1–4) | 2.4 (1.0–7.5) | – | 264 (± 59) | – | 11 | – | ||
| Fukami et al. (2017) | H1 (n = 282) | 29 | 49‡ | 3.5 ± 3.7 | 32 | 204 (± 85) | 616 ± 720 | 17 | 0.4 | [28] |
| H2 (n = 78) | 10 | 31 | 2.5 ± 1.5 | 13 | 188 (± 93) | 694 ± 721 | 12 | 1.3 | ||
Studies published in 2010 and thereafter that provided the denominator of patients initially treated (i.e. initial number of patients who underwent hepatectomy) were included.
†Clavien grade II+ complications.
‡Percentage of patients with >1 metastases.
§Percentage of patients with metastases >5 cm.
¶Clavien grade III+ complications.
H1: Single hepatectomy; H2: Second hepatectomy; H3: Third hepatectomy.