Table 2. . Summary of published experience with radioembolization in liver metastases from neuroendocrine tumors, breast cancer and uveal melanoma.
| Study (year) | Study design | Microsphere type | Treatment setting | n/n with response | Response (%) | Median survival (months) | Ref. | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Complete | Partial | Stable disease | Any | Progressive disease | |||||||
| NET | |||||||||||
| Rhee et al. (2008) | Prospective | SIR-Spheres, TheraSphere | Salvage | 42/29 | 0 | 52 | 41 | 93 | 7 | 25.0 | [79] |
| Kennedy et al. (2008) | Retrospective | SIR-Spheres | NA | 168/148 | 3 | 67 | 25 | 95 | 5 | 70.0 | [80] |
| King et al. (2008) | Prospective | SIR-Spheres | Salvage | 34/34 | 15 | 35 | 15 | 65 | 35 | 27.6 | [81] |
| Saxena et al. (2010) | Retrospective | SIR-Spheres | Salvage | 48/48 | 15 | 40 | 23 | 78 | 22 | 35.0 | [82] |
| Cao et al. (2010) | Retrospective | SIR-Spheres | Mixed | 58/51 | 12 | 27.5 | 27.5 | 67 | 33 | 36.0 | [83] |
| Breast cancer | |||||||||||
| Cianni et al. (2013) | Retrospective | SIR-Spheres | Salvage | 52/52 | 0 | 56 | 33 | 89 | 10 | 11.5 | [84] |
| Jakobs et al. (2008) | Retrospective | SIR-Spheres | Salvage | 30/23 | 0 | 61 | 35 | 96 | 4 | 11.7 | [85] |
| Coldwell et al. (2007) | Retrospective | SIR-Spheres | Salvage | 44/36 | 0 | 47 | 47 | 94 | 6 | NA | [86] |
| Bangash et al. (2007) | Prospective | TheraSphere | Salvage | 27/23 | NA | 39 | 52 | 91 | 9 | NA | [87] |
| Uveal melanoma | |||||||||||
| Gonsalves et al. (2011) | Retrospective | SIR-Spheres | Salvage | 32/32 | 3 | 3 | 56 | 62 | 38 | 10.0 | [88] |
Studies in this table included more than 25 patients.
NA: Not available.