Table 3. . Characteristics of commercially available yttrium-90 microspheres for radioembolization.
SIR-Spheres† | TheraSphere‡ | |
---|---|---|
Isotope | 90Y | 90Y |
Half-life (h) | 64.1 | 64.1 |
Microsphere material | Resin | Glass |
Microsphere diameter (μm) | 20–60 | 20–30 |
Approximate activity per microsphere (Bq) | 50 | 2500 |
Number of microspheres per 3 GBq | 40–80 × 106 | 1.2 × 106 |
Specific gravity (g/ml) | 1.6 | 3.2 |
Embolic effect | Moderate | Mild |
Contrast agent injection | During infusion | None |
Indication | USA (FDA PMA): colorectal liver metastases | USA (FDA HDE): hepatocellular carcinoma |
†Sirtex Medical, North Sydney, Australia.
‡BTG International Canada Inc., Ontario, Canada.
HDE: Humanitarian device exemption; PMA: Premarket approval.