Table 2. . Frequency of malignant transformation of hepatocellular adenoma and risk factors.

Frequency	In largest surgical series: from 4.2 to 10.6%
Risk factors	Male gender, women older than 50 years or younger than 15 years?
	Larger size
	Specific clinical background (androgens, GSD, vascular diseases)
	β-catenin activation: β-HCA and β-IHCA

GSD: Glycogen storage disorder; HCA: Hepatocellular adenoma; IHCA: Inflammatory hepatocellular adenoma.