Table 3.
Parameters describing the plateau (A), plasma appearance (Ka), and plasma elimination (Ke) kinetics as well as the area under the curve (AUC) based on modeled plasma responses
| Parameter | D9-T from D9-TAc (1) | D9-TP from D9-TP (2) | D9-T from D9-TP (3) | P value | ||||
|---|---|---|---|---|---|---|---|---|
| Estimate | SD | Estimate | SD | Estimate | SD | 1 vs. 2 | 1 vs. 3 | |
| A (plateau) | 0.414 | 0.129 | 0.758 | 0.778 | 0.315 | 0.109 | 0.34 | 0.11 |
| N | 6.388 | 1.817 | 6.644 | 1.064 | 7.021 | 1.720 | 0.74 | 0.56 |
| Ka | 0.040 | 0.014 | 0.119 | 0.058 | 0.026 | 0.009 | 0.01 | 0.01 |
| Ke | 0.438 | 0.160 | 0.396 | 0.098 | 0.220 | 0.062 | 0.51 | 0.00 |
| Half-life | 1.58 | 1.75 | 3.15 | |||||
| AUC/(AUC for D9-T from D9-TAc) | 100.0 | 34.5 | 107.3 | |||||
A = plateau (µM/(µmol/kg BW)), N = number of compartments (lag factor), Ka = appearance rate (h-1), Ke = elimination rate (h-1), half-life (h), AUC (%) = area under the curve, based on modeled data extrapolated to 240 h.