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. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Nature. 2018 Apr 11;556(7701):370–375. doi: 10.1038/s41586-018-0035-0

Extended Data Figure 8. Loss of Aspm disrupts centriole duplication in ferret embryonic fibroblasts.

Extended Data Figure 8

Mitotic Aspm KO FEF, identified by staining for pH3 and co-stained for the centriolar marker Centrin, display a significant loss of centrioles. The percentage of cells with an abnormal number (less than 4) of centrioles is increased 8-fold in Aspm−/− FEF compared to Aspm+/+ FEF (n = 100 cells/genotype/independent experiments; P = 0.003). The experiments were repeated 3 times independently with similar results. Statistical analysis was performed by two-tailed t-test and the graph shows mean ± s.e.m.