Table 1.
Baseline characteristics of the 80 enrolled subjects, comparing those who achieved a 90 d good outcome (mRS 0–1) compared to those who did not (mRS 2–6).
| All Subjects (n=80) | 90 d mRS 0–1 (n=31) | 90 d mRS 2–6 (n=49) | p-value | |
|---|---|---|---|---|
| Age, years | 67.5±13.5 | 67.2±15.2 | 67.6±12.5 | 0.73 |
| Male sex (%) | 43 (53.8%) | 19 (61.3%) | 24 (49.0%) | 0.36 |
| Race White (%) | 47 (58.8%) | 22 (71.0%) | 25 (51.0%) | 0.10 |
| Lacunar Subtype (vs non-lacunar)* | 21 (26.6%) | 4 (13.3%) | 17 (34.7%) | 0.06 |
| Pre-stroke mRS 0–1 | 69 (86.3%) | 30 (96.8%) | 39 (79.6%) | 0.04 |
| Medical History† (%) | ||||
| Current Smoker** | 18 (22.5%) | 3 (9.7%) | 15 (30.6%) | 0.03 |
| Dementia | 6 (7.5%) | 0 (0%) | 6 (12.2%) | 0.07 |
| Hypertension | 58 (72.5%) | 19 (61.3%) | 39 (79.6%) | 0.12 |
| Initial NIHSS | 7 (4–13.5) | 6 (4 – 9) | 10 (5 – 17) | 0.01 |
| Blood Glucose, mg/dL | 120 (103.5–172.5) | 122 (100 – 159) | 118 (105 – 188) | 0.25 |
| Systolic Blood Pressure, mm Hg | 155.5 (143.5–171) | 150 (136 – 168) | 162 (149 – 172) | 0.04 |
| Diastolic Blood Pressure, mm Hg | 83 (72.5–92) | 79 (75 – 90) | 85 (72 – 92) | 0.94 |
| Initial INR‡ | 1.00 (0.96–1.10) | 1.00 (0.90 – 1.10) | 1.00 (0.96 – 1.10) | 0.63 |
| FLAIR Signal Intensity Ratio | 1.08 (1.02–1.12) | 1.08 (1.02–1.12) | 1.08 (1.03–1.12) | 0.81 |
| FLAIR Negative (%) | 40 (50.0%) | 13 (41.9%) | 27 (55.1%) | 0.36 |
| Total alteplase dose, mg | 73·7±14·2 | 72·9±14·1 | 74·3±14·4 | 0.68 |
| Symptom Discovery to thrombolysis, h | 3·48 (2·90–4·01) | 3·68 (2·83 – 4·03) | 3·18 (2·90 – 3·93) | 0·52 |
| Last Known Well to thrombolysis, h | 11·24 (9·46–13·26) | 11·13 (8·85 – 14·40) | 11·25 (9·52– 12·93) | 0·90 |
| Arrival-to-thrombolysis, h§ | 1.78 (1.40–2.25) | 1.94 (1.33–2.40) | 1.77 (1.47–2.12) | 0.66 |
| Arrival-to-MRI, h§ | 0.85 (0.58–1.28) | 0.89 (0.60–1.67) | 0.80 (0.58–1.23) | 0.32 |
| MRI-to-thrombolysis, h | 0.89 (0.68–1.05) | 0.80 (0.52–0.95) | 0.97 (0.72–1.10) | 0.02 |
| Any ICH at 24h | 22 (27.5%) | 6 (19.4%) | 16 (32.7%) | 0.21 |
| Stroke upon awakening† | 57 (71.3) | 21 (67.7%) | 36 (73.5%) | 0.62 |
Data are mean±SD, n (%), or median (IQR). INR, international normalized ratio; NIHSS, NIH Stroke Scale.
*
The stroke mimic who had 90-day mRS<2 group was excluded since no stroke subtype could be assigned.
†
Subjects were assumed to not have the condition unless explicitly documented as present.
**
Current smokers are compared to everyone else, including past smokers, never smokers, and unknown status.
‡
Two subjects were missing initial INR in the mRS>1 group.
§
Excluding one subject with symptom discovery after arrival.