Table 3.
No ICH at 24 h (n=58) | Asymptomatic ICH at 24 h (n=21) | p value | |
---|---|---|---|
Age (±SD) | 68±13 | 66±15 | 0.56 |
Male (%) | 33 (56.9%) | 9 (42.9%) | 0.31 |
Race White (%) | 36 (62.1%) | 11 (52.4%) | 0.45 |
Lacunar Subtype (vs. non-lacunar)* | 21 (36.8%) | 0 (0%) | <0.001 |
Pre-stroke mRS 0–1 | 49 (84.5%) | 19 (90.5%) | 0.72 |
Medical History† (%) | |||
Atrial Fibrillation | 9 (15.5%) | 12 (57.1%) | <0.001 |
Initial NIHSS | 5.5 (4–10) | 16 (10–19) | <0.001 |
Blood Glucose, mg/dL | 119.5 (102–180) | 118 (104–160) | 0.65 |
Systolic Blood Pressure, mm Hg | 158 (143–171) | 150 (148–171) | 0.66 |
Diastolic Blood Pressure, mm Hg | 82.5 (72–89) | 84 (73–93) | 0.49 |
Initial INR‡ | 1.00 (0.90–1.07) | 1.08 (1.00–1.10) | 0.04 |
FLAIR Signal Intensity Ratio | 1.08 (1.02–1.11) | 1.10 (1.03–1.13) | 0.08 |
FLAIR Negative (%) | 28 (48.3%) | 12 (57.1%) | 0.61 |
Total alteplase dose, mg | 72.7±14.1 | 75.9±14.4 | 0.37 |
Symptom Discovery to thrombolysis, h | 3.62 (3.02–4.03) | 3.00 (2.83–3.75) | 0.02 |
Last Known Well to thrombolysis, h | 11.62 (10.23–13.42) | 10.53 (7.93–12.67) | 0.13 |
Arrival-to-thrombolysis, h§ | 1.78 (1.40–2.23) | 1.76 (1.43–2.30) | 0.98 |
Arrival-to-MRI, h§ | 0.89 (0.58–1.28) | 0.73 (0.57–1.06) | 0.55 |
MRI-to-thrombolysis, h | 0.86 (0.62–1.02) | 0.90 (0.73–1.07) | 0.41 |
Stroke upon awakening† | 44 (75.9%) | 12 (57.1%) | 0.16 |
Data are mean±SD, n (%), or median (IQR). ICH, intracranial hemorrhage, INR, international normalized ratio.
The stroke mimic who had no ICH was excluded since no stroke subtype.
Subjects were assumed to not have the condition unless explicitly documented in their medical record.
Current smokers are compared to everyone else, including past smokers, never smokers, and unknown status.
Two subjects were missing initial INR in the no-ICH group.
Excluding one subject with symptom discovery after arrival.