Table 4.

Scope of the iron(III)-catalyzed carbonyl-olefin metathesis reaction for the synthesis of PACs.

Conditions: biaryl (0.13 mmol), FeCl₃ (5 mol%), in DCE (0.1M), rt, 1–12 h;

^areaction heated to 50°C;

^breaction was run with 20 mol% catalyst loading;

^cstarting material is bis-prenylated biaryl ketone (see Supporting Information For details);

^dsubstrate is the prenylated analog of 22i; reaction was run in toluene as solvent;

^estarting material is reisolated;

^fsubstrate decomposition was observed at the elevated reaction temperatures;

^glow solubility in organic solvents.