The line graphs represent the direction and slope of interaction effect of central obesity and the clustering of the other 4 MetS risk factors (high fasting blood glucose, high triglycerides, low HDL and high systolic and diastolic BP) on adipokines including TNF-α (A), leptin (B) and adiponectin (C) in Hong Kong Chinese women categorized into four groups: 1) subjects with none of the cardiometabolic risk factors (N4RF_NO; n = 20), 2) subjects with only central obesity without the other 4 MetS cardiometabolic risk factors (N4RF_O; n = 35), 3) subjects without central obesity but with the other 4 MetS cardiometabolic risk factors (4RF_NO; n = 9), and 4) subjects with all five MetS cardiometabolic risk factors (4RF_O; n = 19). Data are expressed in estimated marginal means. Statistical significance was accepted at P < 0.05.