Table 2. Model inputs for probabilities, utilities and costs.

Parameter	Base case value	Range of variation	Basis of variation	References
Unit costs (in 2016 €)
Stent
Everolimus-eluting stent (EES)	847	424–1,271	±50%; uniform	[12]
Bare metal stent (BMS)	440	220–660	±50%; uniform	[12]
Myocardial infarction (MI)
Initial STEMI, discharged alive	926	463–1,389	±50%; uniform	[12]
Initial STEMI, discharged dead	1,817	909–2,726	±50%; uniform	[12]
Repeat MI, discharged alive	2,846	1423–4,269	±50%; uniform	[12]
Repeat MI, discharged dead	3,737	1869–5,606	±50%; uniform	[12]
Stent thrombosis (STT) event
Initial event, discharged alive	926	463–1,389	±50%; uniform	[12]
Initial event, discharged dead	1,817	909–2,726	±50%; uniform	[12]
Repeat event, discharged alive	2,846	1423–4,269	±50%; uniform	[12]
Repeat event, discharged dead	3,737	1869–5,606	±50%; uniform	[12]
Revascularization
Coronary artery bypass graft (CABG)	16,068	8,034–24,102	±50%; uniform	[12]
Percutaneous coronary intervention (PCI) without MI	1,920	960–2880	±50%; uniform	[12]
Annual cardiovascular outpatient treatment and drug costs (excluding revascularization therapy costs)	327	164–491	±50%; uniform	Assumption1
Long-term annual cardiovascular treatment costs after year 5 (including revascularization therapy costs)	1,135	568–1,703	±50%; uniform	[13, 14]
Anti-platelet therapy costs after revascularization event (12 months)	240	120–360	±50%; uniform	Assumption2
Life expectancy (in years)
5-year follow-up survivors	*		±25%; triangular	[8],[9]
Utility scores and decrements
Baseline utility score			±25%; triangular	[10]
Initial STEMI event
First year after event	-0.120	-0.090 - -0.150	±25%; triangular	[11]
Subsequent years after event	-0.085	-0.064 - -0.106	±25%; triangular	[11]
Repeat MI event
First year after event	-0.060	-0.045 - -0.075	±25%; triangular	Assumption3
Subsequent years after event	-0.043	-0.032 - -0.054	±25%; triangular	Assumption3
STT event
First year after event	-0.060	-0.045 - -0.075	±25%; triangular	Assumption3
Subsequent years after event	-0.043	-0.032 - -0.054	±25%; triangular	Assumption3
Revascularization (CABG or PCI)
First year after event	-0.060	-0.045 - -0.075	±25%; triangular	Assumption4
Subsequent years after event	0.000		NA	Assumption5
Decrement due to ageing	*		±25%; triangular	[10]

EES = everolimus-eluting stent. BMS = bare metal stent. MI = myocardial infarction. STEMI = ST-segment elevation myocardial infarction. STT = stent thrombosis. CABG = coronary artery bypass graft. PCI = percutaneous coronary intervention.

* = age dependent

¹ = assumed to be half as high as long-term annual cardiovascular treatment costs.

² = assumed to cost around €20 per month for a duration of twelve months.

³ = assumed to affect utility only half as much as the initial STEMI event.

⁴ = assumed to have the same impact on utility as repeat MI or STT events for a year.

⁵ = no effect was assumed for subsequent years.