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. 2018 Aug 16;13(8):e0202530. doi: 10.1371/journal.pone.0202530

Table 1. Pathways of orthologous genes differentially expressed in both experimental de/remyelination and MS lesions.

Pathway p-value q-value source members
WM + cortical MS lesion versus experimental demyelination
stearate biosynthesis 0.0004 0.006 HumanCyc ACSL1; ELOVL1
cholesterol biosynthesis 0.0006 0.006 Wikipathways MVD; DHCR7
PPAR signaling pathway 0.0006 0.006 KEGG LPL; ACSL1; ANGPTL4
synthesis of very long-chain fatty acyl-CoAs 0.0008 0.006 Reactome ACSL1; ELOVL1
omega-3 fatty acid metabolism 0.0009 0.006 EHMN ACSL1; ELOVL1
activation of gene expression by SREBP (SREBF) 0.001 0.006 Wikipathways MVD; DHCR7
metabolism of lipids and lipoproteins 0.001 0.006 Reactome SYNJ2; ACSL1; DHCR7; LPL; MVD; ELOVL1
fatty Acyl-CoA biosynthesis 0.001 0.006 Reactome ACSL1; ELOVL1
cholesterol biosynthesis 0.002 0.0065 Reactome MVD; DHCR7
activation of gene expression by SREBF (SREBP) 0.002 0.0065 Reactome MVD; DHCR7
superpathway of cholesterol biosynthesis 0.002 0.007 HumanCyc MVD; DHCR7
regulation of cholesterol biosynthesis by SREBP (SREBF) 0.002 0.007 Reactome MVD; DHCR7
amb2 Integrin signaling 0.0025 0.007 PID RAP1A; JAM3
omega-6 fatty acid metabolism 0.003 0.009 EHMN ACSL1; ELOVL1
fatty acid beta oxidation 0.005 0.01 Wikipathways ACSL1; LPL
triglyceride biosynthesis 0.006 0.01 Reactome ACSL1; ELOVL1
class I PI3K signaling events 0.009 0.02 PID CYTH1; RAP1A
integrated breast cancer pathway 0.009 0.02 Wikipathways XRCC3; RAP1A
WM + cortical MS lesion versus experimental remyelination
glial cell differentiation 0.0002 0.006 Wikipathways MBP; MAG
osteoclast differentiation 0.0003 0.006 KEGG TYROBP; TNFRSF1A; CYBA; TREM2
other semaphorin interactions 0.001 0.02 Reactome TYROBP; TREM2
RANKL 0.002 0.02 NetPath TYROBP; TREM2
basigin interactions 0.002 0.02 Reactome SLC7A7; MAG
spinal cord injury 0.003 0.02 Wikipathways MBP; AIF1; MAG
hiv-1 nef: negative effector of fas and tnf 0.008 0.04 BioCarta GSN; TNFRSF1A
cardiac hypertrophic response 0.0085 0.04 Wikipathways FGFR2; TNFRSF1A
DAP12 signaling 0.009 0.04 Reactome TYROBP; FGFR2; TREM2
caspase cascade in apoptosis 0.009 0.04 PID GSN; TNFRSF1A