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. 2018 Aug 6;16(8):e2005651. doi: 10.1371/journal.pbio.2005651

Fig 7. TRPP2 and SLC25A25 act in a common signaling cascade required for vertebrate left–right patterning.

Fig 7

(A) Conceptually, our data imply a function of SLC25A25 (Slc25a25b) between flow-mediated asymmetric activation (green) of TRPP2-dependent Ca2+ signaling in KV and Nodal-dependent asymmetric gene expression in the lateral plate mesoderm (red). (B) Randomized left–right asymmetry in pkd2-morphant zebrafish (pkd2MO; *P = 6 × 10−21) was partially rescued by expression of slc25a25b mRNA (*P = 4 × 10−6). (C) Randomized left–right asymmetry in pkd2-null (pkd2−/−) zebrafish (*P = 9 × 10−15) was not rescued by expression of slc25a25b mRNA (*P = 0.27). Numbers of embryos are indicated above bars. L = left; S = symmetric; R = right. (D) Schematic of functional coupling of TRPP2 and SLC25A25. For numerical values, see S1 Data. KV, Kupffer’s vesicle; SLC25A25, solute carrier 25 A 25; TRPP2, transient receptor potential channel polycystin-2.