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. 2018 Aug 6;14(8):e1007234. doi: 10.1371/journal.ppat.1007234

Fig 5. IFNαR-dependent regulation of caspase 8 during IOE infection.

Fig 5

(A) Detection of full length (C8), and cleaved caspase 8 (CC8) and β-actin in BM cell lysates from mock and infected WT and Ifnar1-/- mice 7d.p.i. Lanes represent individual mice. (B) Relative amounts of C8 and CC8 p41/43 and CC8 p18 in WT and Ifnar1-/- mock and IOE–infected mice 7 d.p.i., normalized to β-actin. (C) HSPCs and HSCs in mock and vehicle (veh) control- or zVAD-FMK-treated infected WT and Ifnar1-/- mice 7 d.p.i. n = 5–13 mice/group. (D) Vehicle-, zVAD-FMK-treated, or zVAD-FMK- and Necrostatin-1s treated Ifnar1-/- mice day 7 p.i. n = 3–5 mice/group. *P < 0.05, **P < 0.001, ***P < 0.0001.