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. 2018 Aug 6;14(8):e1007234. doi: 10.1371/journal.ppat.1007234

Fig 6. Targeting RIPK3 kinase activity protects HSPCs from IOE infection-induced depletion in mixed BM chimeric mice.

Fig 6

(A-C) BM cellularity (A), HSPCs (B), and HSCs (C) in mock or infected WT and Ripk3Δintron2 mice 7 d.p.i. n = 4–5 mice/infected group; n = 2–4 mice/mock group. (D) Generation and treatment of Ripk3Δintron2:WT mixed BM chimeric mice, and numbers of HSPCs and HSCs in mock and IOE-infected chimeric mice 7 d.p.i. (E) Numbers of WT (white bars) and Ripk3Δintron2 (green bars) HSPCs and HSCs in mock and IOE-infected chimeric mice 7 d.p.i. n = 5–6 mice/group.*P < 0.05, **P < 0.01.