Table 1. Pathogen Box compounds tested for dose response against G. lamblia.
| Common name | MMV Compound ID | G. lamblia EC50 | HepG2 CC50 (μM) (this study) | HepG2 CC50 (μM) (literature values) |
|---|---|---|---|---|
| (μM) | (μM) | |||
| Nifurtimox | MMV001499 | 0.64 ± 0.12 | >40 | >80*^ |
| N/A | MMV022478 | 2.41 ± 0.12 | >40 | >10* |
| N/A | MMV028694 | 3.88 ± 1.27 | 15.87 | 8.10* |
| N/A | MMV495543 | 2.77 ± 0.21 | >40 | 47.60* |
| N/A | MMV676395 | 1.57 ± 0.20 | >40 | >100* |
| Clofazimine | MMV687800 | 1.79 ± 0.23 | 26.43 | >20+ |
| N/A | MMV687807 | 0.51 ± 0.06 | <5 | 0.70* |
| N/A | MMV687812 | 1.25 ± 0.12 | 5.33 | 3.90* |
| Delamanid | MMV688262 | 0.55 ± 0.04 | >40 | 72.50* |
| N/A | MMV688755 | 1.57 ± 0.38 | >40 | >50* |
| N/A | MMV688844 | 2.30 ± 0.43 | >40 | >50* |
| Auranofin | MMV688978 | 3.74± 0.46 | 0.50 | 4.50# |
| Nitazoxanide | MMV688991 | 0.80 ± 0.10 | 10.73 | 6.35*^ |
* Pathogen_Box_Activity_Biological_Data_ Structure & Smiles (https://www.pathogenbox.org/about-pathogen-box/composition)
N/A–not applicable;
^ HepG2 CC20 (μM)
+ reference [41];
# reference [56]