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. 2018 Aug 6;12(8):e0006673. doi: 10.1371/journal.pntd.0006673

Table 2. Representative set of dual hits against Giardia and Cryptosporidium with ≥ 75% inhibition.

EC50: 50% effective concentration, CC50: 50% cytotoxic concentration, % inh: percentage inhibition.

Common name MMV Compound ID G. lamblia EC50 (μM) C. parvum EC50 (μM) HepG2 CC50 (μM) (this study) HepG2 CC50 (μM) (literature values)
Iodoquinol MMV002817 2.52 ± 0.45 0.48± 0.2 ~40 2.50*^
N/A MMV010576 1.9 ± 0.28 2.99 ± 2.1 >40 >10*
N/A MMV028694 3.88 ± 1.27 1.56 ± 0.5 15.87 8.10*
N/A MMV676501 1.40 ± 0.2 4.96 ± 1.8 >40 50.10*
Clofazimine MMV687800 1.79 ± 0.2 3.33 ± 1.2 26.43 >20+
Auranofin MMV688978 3.74 ± 0.46 3.34 ± 2.7 0.50 4.50#
Nitazoxanide MMV688991 0.80 ± 0.10 3.10 ± 0.4 10.73 6.35*^

* Pathogen_Box_Activity_Biological_Data__ Structure & Smiles (https://www.pathogenbox.org/about-pathogen-box/composition)

N/A–not applicable;

^ HepG2 CC20 (μM)

+ reference [41];

# reference [56]