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. Author manuscript; available in PMC: 2019 Sep 5.
Published in final edited form as: Int J Pharm. 2018 Jul 5;548(1):642–648. doi: 10.1016/j.ijpharm.2018.07.018

FIGURE 3.

FIGURE 3.

Lyso-PS-mediated hypo-responsiveness involves TIM-4 receptor. (A) Immunization schedule used for TIM-4 immunogenicity study. Open circles (○) represent SC immunizations during the pre-exposure period and the closed triangles (▾) represent rechallenge injections of free FVIII. The closed squares (∎) represent the terminal samples. (B) Total anti-FVIII antibody titers (mean ± SEM) after rechallenge with free FVIII at week 9. * denotes statistical significance with p < 0.05 by one-way ANOVA with Tukey’s post-hoc analysis.