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. Author manuscript; available in PMC: 2018 Aug 16.
Published in final edited form as: J Causal Inference. 2016 Nov 8;4(2):20160009. doi: 10.1515/jci-2016-0009

Table 2.

Correlated confounders X and U: Omitted variable bias (OVB) and imbalance before and after adjusting for X*.

Initial OVB and Imbalance OVB and Imbalance after adjusting for X*
Omitted variable bias OVB(τ̂ | {}) = αXβX + αUβU + αXρβU + αUρβX
OVB(τ^X)=αUβU(1-ρ2)+(αXβX+αXρβU+αUρβX)(1-γ)1-(αX+αUρ)2γ
Imbalance in U Imbalance(U | {}) = αU + αXρ
Imbalance(UX)=αU(1-ρ2)+αXρ(1-γ)1-(αX+αUρ)2γ
Imbalance in X Imbalance(X|{}) = αX + αUρ
Imbalance(XX)=(αX+αUρ)(1-γ)1-(αX+αUρ)2γ
Effect of conditioning on X* when …
biases are in same the direction biases offset each other
Absolute omitted variable bias Increase in OVB is most likely if
  1. the bias induced by the unobserved confounder U is much larger than the bias induced by confounder X and the correlation between X and U is low, or

  2. confounder X strongly affects Z –a high correlation between X and U strongly boosts bias amplification.

Whether OVB increases strongly depends. on the signs and magnitudes of all five parameters. If the biases induced by X and U strongly offset each other, an increase in OVB almost surely results – unless the correlation between X and U is close to 1.
Absolute imbalance Imbalance in U may increase or decrease.
Imbalance in X always decreases.
Imbalance in U may increase or decrease.
Imbalance in X always decreases.
Effect of measurement error Attenuates any increase in OVB and attenuates any decrease in OVB. Attenuates any increase in OVB (and might even turn an increase into a decrease) but may attenuate or strengthen any decrease in OVB.