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. 2018 Jul 30;7:e35755. doi: 10.7554/eLife.35755

Figure 4. Ergot alkaloid action against adult S. mansoni parasites ex vivo.

Figure 4.

(A) Serotonin induced increase in movement of S. mansoni adult male (M, solid circles) and female (F, open circles) parasites. (B) Adult S. mansoni movement in the absence of drug (black trace), following 5-HT addition (200 µM, blue), or exposure to a Sm.5HTRL antagonist (BOL-148, 1 µM) and subsequent 5-HT (200 µM, red) addition. (C) Dose-response curves for Sm.5HTRL agonist evoked stimulation of adult schistosome movement. Ergot alkaloids = solid symbols, 5-HT = open blue circles. (D) Dose-response curves for Sm.5HTRL antagonist inhibition of 5-HT (200 µM) evoked movement. Worm movement data (A, C–D) reflect mean ± standard error of the mean for at least 3 biological replicates.