Figure 5. Ergot alkaloid agonists evoke an acute hepatic shift of parasites in vivo.

(A) Location of mouse vasculature dissected after drug treatment to resolve worm location. Adult parasites normally reside in the mesenteric vasculature (i), but following anthelmintic treatment shift to the portal vein (ii) and liver (iii). (B) Left, quantification of percent worm burden found in either the mesenteries, portal vein or liver following treatment with DMSO (negative control), praziquantel (100 mg/kg, positive control) and various ergot alkaloid compounds. Diameter of circle represents proportionality of distribution. Right, bar chart represents efficacy of the same series of compounds at Sm.5HTR_L.