Figure 4.
Retinal mRNA (mean ± SEM) expression after 3, 7 and 14 days of metabolic acidosis normalized to control expression for each gene. The genes were carbonic anhydrase II and XIV (CA-II and CA-XIV), acid-sensing ion channels 1 and 4 (ASIC-1 and ASIC-IV), anion exchange protein 3 (AEP-3) and Na+/H+ exchanger 1 (NHE-1). Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was a control gene that was not expected to change. One asterisk: significantly different at p<0.05. Two asterisks: significantly different at p <0.01.; three asterisks: significantly different at p ≤ 0.001.