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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Cancer Res. 2018 Jun 11;78(16):4459–4470. doi: 10.1158/0008-5472.CAN-17-3226

Fig. 3. Ablation of FGF signaling reduces DNA methylation in the Ldhb promoter.

Fig. 3

A. Methylated DNA was immunoprecipitated and subjected to high-throughput sequencing. The level of methylation at CpG islands in the Ldhb promoter region is shown. B. Bisulfite DNA sequencing of the Ldhb promoter area in MEFΔF cells. C&D. Real-time RT-PCR and western blot analyses showing increased Tet1 in MEFΔF cells at the mRNA and protein levels. E. Real-time RT-PCR analyses of ldha and Ldhb in Tet1 null MEF (ΔTet1). *, P < 0.05.